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Increased level of p21 in human ovarian

Increased level of p21 in human ovarian tumors is associated with increased expression of CDK2, cyclin A and PNCA

✍ Nadia Barboule; Véronique Baldin; Suzanne Jozan; Simone Vidal; Annie Valette 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 169 KB 👁 1 views

We have demonstrated over-expression of the cyclindependent kinase inhibitor p21 in various ovarian-cancer cell lines as well as in ovarian-tumor biopsies. This increase in p21 expression relative to that observed in normal ovarian epithelial cells is unrelated to proliferation index. In the present