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Is benign rolandic epilepsy genetically determined?

✍ Scribed by Lata Vadlamudi; A. Simon Harvey; Mary M. Connellan; Roger L. Milne; John L. Hopper; Ingrid E. Scheffer; Samuel F. Berkovic

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 62 KB
Volume: 56
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.20153

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✦ Synopsis

Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0-0.4) for BRE compared with 0.7 (95% CI, 0.5-0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored.

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