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Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

✍ Scribed by Christopher A. McDevitt; Emily Crowley; Gemma Hobbs; Kate J. Starr; Ian D. Kerr; Richard Callaghan

Book ID: 111312560
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 257 KB
Volume: 275
Category: Article
ISSN: 1432-1327
DOI: 10.1111/j.1742-4658.2008.06578.x

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## Abstract The transporter associated with antigen processing (TAP) translocates peptides from their site of generation in the cytosol to the lumen of the endoplasmic reticulum for binding to MHC class Imolecules. TAP is a member of the ATP‐binding cassette (ABC) transporter family whose members u