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Is alpha-Pinene a Substrate for Permeability-Glycoprotein in Wood Rats?

✍ Scribed by Adam K. Green; Shannon L. Haley; David M. Barnes; M. Denise Dearing; William H. Karasov


Book ID
106408945
Publisher
Springer
Year
2006
Tongue
English
Weight
380 KB
Volume
32
Category
Article
ISSN
0098-0331

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The objective of this study is to investigate the role of P-glycoprotein (P-gp), a membrane efΒ―ux pump associated with multidrug resistance (MDR) and a known substrate for tacrolimus, in determining the regional intestinal permeability of tacrolimus in rats. Thus, isolated segments of rat jejunum, i