Tacrolimus is a class II low-solubility
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Shigeki Tamura; Atsuo Ohike; Rinta Ibuki; Gordon L. Amidon; Shinji Yamashita
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Article
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2002
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John Wiley and Sons
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English
β 152 KB
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The objective of this study is to investigate the role of P-glycoprotein (P-gp), a membrane efΒ―ux pump associated with multidrug resistance (MDR) and a known substrate for tacrolimus, in determining the regional intestinal permeability of tacrolimus in rats. Thus, isolated segments of rat jejunum, i