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Is advanced age associated with increased incidence and severity of chemotherapy-induced peripheral neuropathy?

✍ Scribed by Andreas A. Argyriou; Panagiotis Polychronopoulos; Angelos Koutras; Gregoris Iconomou; Philippos Gourzis; Konstantinos Assimakopoulos; Haralabos P. Kalofonos; Elisabeth Chroni


Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
116 KB
Volume
14
Category
Article
ISSN
0941-4355

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## Abstract Mice with a disrupted gp49B gene, which encodes gp49B1 that is expressed on certain hematopoietic cells and has two immunoreceptor tyrosine‐based inhibitory motifs (ITIM), exhibit augmented FcϵRI‐initiated mast cell degranulation and resultant tissue edema. gp49B1‐deficient (__gp49B^–/–