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Is a Two-State Solution Still Viable?

✍ Scribed by Stephen P. Cohen; Michael C. Hudson; Nathan Guttman; Khalil E. Jahshan


Book ID
108574368
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
224 KB
Volume
10
Category
Article
ISSN
1061-1924

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## Abstract Thermal unfolding (or folding) in many proteins occurs in an apparent two‐state manner, suggesting that only two states, unfolded and folded, are populated. At the melting temperature, __T__~m~, the two states coexist. Using lattice models with side chains we show that individual residu