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Is 11 -hydroxysteroid dehydrogenase type 1 a good therapeutic target for blockade of glucocorticoid actions?

✍ Scribed by Chrousos, G. P.


Book ID
118055172
Publisher
National Academy of Sciences
Year
2004
Tongue
English
Weight
133 KB
Volume
101
Category
Article
ISSN
0027-8424

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✍ Joanna M. Day; Paul A. Foster; Helena J. Tutill; Michael F.C. Parsons; Simon P. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 551 KB

## Abstract Oestradiol (E2) stimulates the growth of hormone‐dependent breast cancer. 17β‐hydroxysteroid dehydrogenases (17β‐HSDs) catalyse the pre‐receptor activation/inactivation of hormones and other substrates. 17β‐HSD1 converts oestrone (E1) to active E2, but it has recently been suggested tha