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Irritability in panic disorder: Effects of imipramine treatment

✍ Scribed by Dr. D. J. Nutt; P. Glue

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 278 KB
Volume: 6
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470060109

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✦ Synopsis

Abstract

To establish the presence and magnitude of irritability in panic disorder, and its relationship with anxiety and depression, ratings of each variable were monitored in 18 patients with panic disorder before and during imipramine treatment. Pretreatment ratings of inward‐and outward‐directed irritability demonstrated borderline levels of morbidity. Over the duration of treatment, irritability ratings fell, and there were substantial reductions in ratings of depression, but only small reductions in ratings of state anxiety. There were a number of significant correlations between pre‐ and post‐treatment ratings of irritability and depression, but little association between these and ratings of anxiety.

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