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Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C

✍ Scribed by Rayudu Gopalakrishna; Zhen Hai Chen; Usha Gundimeda

Book ID
115926639
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
517 KB
Volume
314
Category
Article
ISSN
0014-5793

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## Abstract Protein kinase C (PKC) undergoes specific inactivation by nanomolar concentrations of calphostin C. Both PKC‐α (a Ca^2+^‐dependent conventional isoform) and PKC‐α (a Ca^2+^‐independent novel isoform) are similarly inactivated by calphostin C (75–100 nM produced 50% inhibition), suggesti