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Irreversible inhibition of the leukotriene pathway by 4,5-dehydroarachidonic acid

✍ Scribed by E.J. Corey; Steven S. Kantner; Peter T. Lansbury Jr.

No coin nor oath required. For personal study only.

✦ Synopsis

The 5-lipoxygenase from rat basophilic leukemic cells (RBL-1) is irreversibly deactivated by 4,5_dehydroarachidonic acid in the presence of oxygen.

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