Iron(III) Chelation: Tuning of the pH Dependence by Mixed Ligands

✍ Scribed by Anne-Marie Albrecht-Gary; Sylvie Blanc; Frederic Biaso; Fabrice Thomas; Paul Baret; Gisele Gellon; Jean-Louis Pierre; Guy Serratrice

• Book ID: 102168292
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 226 KB
• Volume: 2003
• Category: Article
• ISSN: 1434-1948
• DOI: 10.1002/ejic.200200643

✦ Synopsis

Abstract

The iron(III) chelating properties of two heteropodands with 8‐hydroxyquinoline and catechol binding groups were examined and compared to those of the corresponding homopodal analogues, O‐TRENSOX and TRENCAMS. Like the parent homopodands, the two heteropodands are based on the TREN scaffold and the chelating units are connected by amide groups, TRENSOX2CAMS having two 8‐hydroxyquinoline and one catechol arms and TRENSOXCAMS2 one 8‐hydroxyquinoline and two catechol moieties. The aqueous coordination chemistry of these ligands was examined by potentiometric and spectrophotometric methods in combination with ^1^H NMR spectroscopy. The respective pFe^III^ values showed a cooperative effect of the mixed chelating units. Moreover, the pFe^III^ dependence on pH showed that the mixed ligands exhibit a higher complexing ability than the parent ligands over the pH range 5−9 which is of biological relevance. This result could be of great interest for medical applications. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)