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Iron overload and mitochondrial diseases

✍ Scribed by Pierre Rustin; Jürgen-Christoph von Kleist-Retzow; Agnès Rötig; Arnold Munnich


Book ID
117298061
Publisher
The Lancet
Year
1998
Tongue
English
Weight
54 KB
Volume
351
Category
Article
ISSN
0140-6736

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Peroxidative decomposition of mitochondrial membrane phospholipids with subsequent mitochondrial dysfunction is a postulated mechanism of liver cell injury in parenchymal iron overload. Malondialdehyde is formed when polyunsaturated fatty acids of membrane phospholipids undergo peroxidative decompos