Iron-dextran carcinogenesis in rats: Influence of dose on the number and types of neoplasm induced

✍ Scribed by F. J. C. Roe; R. L. Carter

• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: French
• Weight: 1005 KB
• Volume: 2
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910020412

✦ Synopsis

and 2 subcutaneous injections vf 0.75 ml iron-dextran (" ltnferon ") at weekly intervals: 64 untreated rats served as controls. Injection site tumours arose in 8, I I , 7 and 8 rats, respectively, in the four groups treated with iron-dextran. The average time of tumour induction was similar in the four test groups but the grade of malignancy of tumours was directly related to the total dose of iron-deextran administered. The wider implications of this latter observation are briefly discussed. The incidence of tumours at locations distant from the injection site was higher in the 128 rats which received only two injections of iron-dextran than in the 64 untreated controls. However, the risk of dying with a distant tuinour was not statistically higher it1 the combined test groups than in the control group. Several of the distant neoplasms in the iron-dextran treated animals were of unusual types but their relationship to treatment with iron-dextran remains uncertain.