Iron chelators of the pyridoxal isonicotinoyl hydrazone class
โ Scribed by D. R. Richardson; G. T. Hefter; P. M. May; J. Webb; E. Baker
- Publisher
- Springer Netherlands
- Year
- 1989
- Tongue
- English
- Weight
- 562 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1572-8773
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๐ SIMILAR VOLUMES
Pyridoxal isonicotinoyl hydrazone and its analogs are orally effective Fe(llI) chelators which show potential as drugs to treat iron overload disease. The present investigation describes the measurement of the partition coefficient of the apochclator and Fe(lll) complex of 20 of these ligands. These
The Belgrade rat has a hypochromic, microcytic anemia inherited as an autosomal recessive mutation. Although transferrin binds normally to reticulocytes and internalizes normally, iron accumulation into cells and heme is much slower than normal. We have investigated the role of the transferrin cycle