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Iron as a potential co-factor in the pathogenesis of Kaposi's sarcoma?

✍ Scribed by Thierry Simonart; Jean-Christophe Noel; Graciela Andrei; Dominique Parent; Jean-Paul Van Vooren; Philippe Hermans; Yanto Lunardi-Yskandar; Charlie Lambert; Tandakha Dieye; Claire-Michèle Farber; Corinne Liesnard; Robert Snoeck; Michel Heenen; Johan R. Boelaert

Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
281 KB
Volume
78
Category
Article
ISSN
0020-7136

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✦ Synopsis

The role of iron in the pathogenesis of several tumours is being increasingly investigated. In particular, its involvement in the pathogenesis of Kaposi's sarcoma (KS) is suggested by the distribution of the endemic form of KS corresponding to continental rifts and associated iron-oxide-rich volcanic clays. We investigated in vitro to what extent iron supplementation or withdrawal could affect the growth of KS-derived cells, by analysing the effects of adding iron salts (iron chloride and ferric nitrilotriacetate) and/or reducing iron by iron chelators (desferrioxamine) on KS-derived cell cultures. The addition of iron salts strongly stimulated the growth of KS cells, as reflected by increase in thymidine incorporation and cell number. Conversely, desferrioxamine and deferiprone inhibited cell growth. The inhibitory effect of iron chelation was more pronounced on rapidly dividing basic fibroblast-growthfactor-stimulated cells. These results may point to a novel therapeutic approach to KS.

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