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Iron and transferrrin uptake by brain and cerebrospinal fluid in the rat

✍ Scribed by Andrew Crowe; Evan H. Morgan

Book ID: 115803475
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 906 KB
Volume: 592
Category: Article
ISSN: 0006-8993
DOI: 10.1016/0006-8993(92)91652-u

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Transferrin (Tf) donates iron (Fe) to the brain by means of receptor-mediated endocytosis of Tf at the brain barriers. As Tf transport through the brain barriers is restricted, Fe is probably released into the brain extracellular compartment as non-Tf-bound iron (NTBI). To evaluate NTBI in the brain