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Iron and insulin resistance: Effect of iron manipulation on insulin receptor in HEPG2 hepatocytes

✍ Scribed by P. Dongiovanni; L. Valenti; G. Occhino; A.L. Fracanzani; M. Mattioli; S. Fargion


Book ID
117372410
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
317 KB
Volume
38
Category
Article
ISSN
0168-8278

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We investigated the effect of phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator on insulin receptors and insulin action in freshly isolated and primary cultures of rat hepatocytes. PMA (1 x 10(-7) M) did not alter insulin receptor numbers or affinity either acutely or chronic