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Irinotecan-induced Diarrhea: Functional Significance of the Polymorphic ABCC2 Transporter Protein

โœ Scribed by de Jong, F A; Scott-Horton, T J; Kroetz, D L; McLeod, H L; Friberg, L E; Mathijssen, R H; Verweij, J; Marsh, S; Sparreboom, A


Book ID
110019905
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
123 KB
Volume
81
Category
Article
ISSN
0009-9236

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Functional characterization of protein v
โœ Rudolf Arlanov; Andrew Porter; Dennis Strand; Rachel Brough; Darja Karpova; Rein ๐Ÿ“‚ Article ๐Ÿ“… 2012 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 596 KB

The multidrug resistance-associated protein 2 (MRP2/ABCC2) is involved in the efflux of endogenous and xenobiotic substrates, including several anticancer and antiviral drugs. The functional consequences of ABCC2 protein variants remain inconsistent, which may be due to shortcomings of the in vitro