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Iridium-Catalyzed Selective Synthesis of 4-Substituted Benzofurans and Indoles via Directed Cyclodehydration

✍ Scribed by Kyoji Tsuchikama; Yu-ki Hashimoto; Kohei Endo; Takanori Shibata

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
183 KB
Volume
351
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

A directed cyclization‐dehydration cascade of α‐aryloxy ketones and α‐arylamino ketones was efficiently catalyzed by a cationic iridium‐BINAP complex, which afforded various types of 4‐substituted benzofurans and indoles in high yields with complete regioselectivity. The newly developed protocol also enabled the enantioselective preparation of chiral 4‐acetyloxindole using a chiral iridium catalyst.

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