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IRF4 at the crossroads of effector T-cell fate decision

✍ Scribed by Huber, Magdalena; Lohoff, Michael

Book ID: 121790981
Publisher: John Wiley and Sons
Year: 2014
Tongue: English
Weight: 779 KB
Volume: 44
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.201344279

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## Abstract To study the role of IL‐12 as a third signal for T‐cell activation and differentiation __in vivo__, direct IL‐12 signaling to CD8^+^ T cells was analyzed in bacterial and viral infections using the P14 T‐cell adoptive transfer model with CD8^+^ T cells that lack the IL‐12 receptor. Resu