IR (vibrational) CD of peptide β-turns: A theoretical and experimental study of cyclo-(-Gly-Pro-Gly-D-Ala-Pro-)
✍ Scribed by Herman R. Wyssbrod; Max Diem
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1992
- Tongue
- English
- Weight
- 506 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0006-3525
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
IR vibrational CD (VCD) has been observed for the cyclic pentapeptide cyclo‐(‐Gly‐Pro‐Gly‐D ‐Ala‐Pro‐) in solution in CDBr~3~. The observed VCD spectra do not resemble the VCD features of any of the previously reported peptide secondary structures, such as α‐helical, “random coil,” or sheet structures, and might be due to the β‐turn contained in this molecule. To shed light onto the origin of the observed spectra, VCD intensity calculations, based on the solution and solid‐state structures of cyclo‐(‐Gly‐Pro‐Gly‐D‐Ala‐Pro‐), have been carried out. In addition, calculated VCD data for pure β‐turns are discussed. © 1992 John Wiley & Sons, Inc.