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Ir-Catalyzed Allylic Amination/Ring-Closing Metathesis: A New Route to Enantioselective Synthesis of Cyclic β-Amino Alcohol Derivatives

✍ Scribed by Lee, Jun Hee; Shin, Seunghoon; Kang, Jahyo; Lee, Sang-gi


Book ID
126866364
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
77 KB
Volume
72
Category
Article
ISSN
0022-3263

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N-Crotonyl-L-proline derived peptides can be transformed to the corresponding b-methyl-b-alanine-L-proline peptides by Yb(OTf) 3 catalysed Michael addition of aliphatic amines to the crotonyl residue. The Michael adducts derived from addition of allylamine are versatile precursors to the correspondi