IQGAP1 regulation and roles in cancer
β Scribed by Michael Johnson; Manisha Sharma; Beric R. Henderson
- Book ID
- 113528311
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 690 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0898-6568
No coin nor oath required. For personal study only.
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## Abstract IQGAP1 is a multifunctional protein involved in actin cytoskeleton assembly and Eβcadherinβmediated cell adhesion. We reported previously IQGAP1 overexpression in human colorectal carcinomas especially at the invasion front (IF) and that such overexpression tended to correlate with lymp
## Abstract IQGAP1 is recognized as a negative regulator of cellβcell adhesion at adherens junctions in several cell types, including gastric mucosal cells. The histopathologic appearance of diffuse gastric carcinoma is defined by nonβ or poorly cohesive tumor cells, indicating abnormal intercellul