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Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models

โœ Scribed by Yan-Ling Yang; Chang-Hong Meng; Jian-Hua Ding; Hai-Rong He; Kevin Ellsworth; Jie Wu; Gang Hu


Book ID
113500640
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
187 KB
Volume
1049
Category
Article
ISSN
0006-8993

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The central nervous system reserves high concentrations of free Zn(2+) in certain excitatory synaptic vesicles. In pathological conditions such as transient cerebral ischemia, traumatic brain injury, and kainic acid (KA)-induced seizure, free Zn(2+) is released in excess at synapses, which causes ne