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Ipsapirone, a 5-HT1A agonist, suppresses REM sleep equally in unmedicated depressed patients and normal controls

✍ Scribed by J. Christian Gillin; Jin-Wook Sohn; Stephen M. Stahl; Michael Lardon; John Kelsoe; Mark Rapaport; Caroline Ruiz; Shah Golshan


Book ID
113387847
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
672 KB
Volume
15
Category
Article
ISSN
1470-634X

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Flesinoxan is a highly potent and selective 5-HTlA full agonist, active in several models of depression. In this pilot open study, flesinoxan (4 mdd) was administered orally for 4 weeks in 16 major depressive, mostly treatmentresistant inpatients exhibiting a score of at least 19 on the Hamilton dep