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Ions and blockers in potassium channels: insights from free energy simulations

✍ Scribed by V.B. Luzhkov; J. Åqvist

Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
373 KB
Volume
1747
Category
Article
ISSN
1570-9639

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✦ Synopsis

Potassium ion channels enable efficient and selective permeation of K + ions across nonpolar biological membranes. Here we review the results of recent free energy calculations related to the permeation of monovalent cations through K + channels and to the channel inhibition by blocker compounds. In particular, the progress in computational studies of the bacterial KcsA channel is discussed.

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