Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis
✍ Scribed by Michael A. Sheard
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 247 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.1020
No coin nor oath required. For personal study only.
✦ Synopsis
CD95 (Fas/APO-1) is a death receptor on the surface of a wide variety of cell types. In most cells examined, ionizing radiation acts as a response-enhancing agent for CD95-mediated cell death. Although DNA-damaging radiation appears to modulate CD95-mediated signals through multiple mechanisms, the only well-characterized mechanism is activation of the tumor-suppressor protein p53, which transcriptionally regulates the expression of CD95 on various cell types. The ligand for CD95 is expressed by activated lymphocytes and natural-killer cells, which produce factors that sensitize cells resistant to CD95-mediated cell death. Ligation of CD95 on irradiated tumor cells might be achievable using emerging modalities that reactivate the stalled anti-tumor immune response.