This study presents a mechanistic QSAR analysis of passive blood-brain barrier permeability of drugs and drug-like compounds in rats and mice. The experimental data represented in vivo log PS (permeability-surface area product) from in situ perfusion, brain uptake index, and intravenous administrati
✦ LIBER ✦
Ionization-Specific QSAR Models of Blood–Brain Penetration of Drugs
✍ Scribed by Kiril Lanevskij; Pranas Japertas; Remigijus Didziapetris; Alanas Petrauskas
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 174 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1612-1872
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## Abstract ## Aims The objective of the present study was to evaluate drug efflux transporter interactions of darifenacin and examine the impact of such transporter interactions on darifenacin permeability in an __in vitro__ model of the blood–brain barrier (BBB) and blood–ocular barrier (BOB).