Ionically Gelled Biopolysaccharide Based Systems in Drug Delivery

✍ Scribed by Amit Kumar Nayak, Md Saquib Hasnain, Dilipkumar Pal

• Publisher: Springer
• Year: 2021
• Tongue: English
• Leaves: 191
• Series: Gels Horizons: From Science to Smart Materials
• Category: Library

✦ Synopsis

This volume provides a thorough insight into the chemistry and mechanism of ionic gelations of various ionic biopolysaccharides, like alginate, gellan gum, pectin, chitosan, carboxymethyl cellulose, etc., and the applications of various ionically gelled biopolysaccharides in drug delivery fields, with chapters emphasizing the recent advances in the field by the experts. This book will be of interest to graduate students and academic and industry researchers from pharmacy, biotechnology, bioengineering, biomedical and material sciences fields.

✦ Table of Contents

Preface
Contents
About the Editors
1 Ionically Gelled Pectinates in Drug Delivery
1 Introduction
2 Ionic Gelation of Natural Polysaccharides
3 Pectin and Ionic Gelation Mechanism of Pectins
4 Drug Delivery Applications of Ionically Gelled Pectins
5 Conclusion
References
2 Ionically Gelled Alginates in Drug Delivery
1 Introduction
2 Alginate
2.1 Sources
2.2 Extraction
2.3 Chemistry
3 Ionic Gelation of Alginate
4 Insights into the Use of Ionically Gelled Alginate-Based Systems for Drug Delivery
4.1 Ionically Gelled Systems Made Up of Alginate as Only Biopolymer
4.2 Ionically Gelled Alginate-Based Systems Prepared Using Alginate and Second Biopolymers
4.3 Ionically Gelled Alginate-Based Systems Prepared Using Alginate and Inorganic Materials
5 Conclusion
References
3 Ionically Gelled Gellan Gum in Drug Delivery
1 Introduction
2 Ionic Gelation Method
3 Ionically Gelled GG in Drug Delivery
3.1 Microspheres
3.2 Hydrogels
3.3 Beads
3.4 Microparticles and Nanoparticles
4 Conclusion and Future Prospective
References
4 Ionic Gelled Chitosan for Drug Delivery
1 Introduction
2 Process of Ionic Gelation
3 Application of Ionic Gelled Chitosan in Drug Delivery
3.1 Ionic Gelled Chitosan Nanoparticles for Drug Delivery
3.2 Ionic Gelled Chitosan Nanoparticles with Efficient Protein Delivery
3.3 Ionic Gelled Chitosan Nanoparticles with Acaricide Potential
3.4 Ionic Gelled Chitosan Nanoparticles with Larvacidal Potential
3.5 Ionic Gelled Chitosan Nanoparticles with Anticancer Drug Delivery
3.6 Ionic Gelled Chitosan Nanoparticles with Antifungal Efficiency
3.7 Ionic Gelled Chitosan Nanocarriers for Effective Biofortification Process
3.8 Ionic Gelled Chitosan Nanocarriers for Drug Delivery in Static Mixers
3.9 Ionic Gelled Chitosan Nanoparticle for Gene Delivery
3.10 Ionic Gelled Chitosan Nanoparticle for Delivery of Tacrine
3.11 Ionic Gelled Chitosan Nanoparticle for Delivery of Amoxicillin
3.12 Ionic Gelled Chitosan Nanoparticle for Effective Delivery of Enzyme
3.13 Ionic Gelled Thiol Functionalized Chitosan Nanoparticle for Mercury Adsorption
3.14 Ionic Gelled Tripolyphosphate-Beta-Cyclodextrin-Chitosan Nanoparticle for Drug Delivery
3.15 Ionic Gelled Chitosan Nanoparticle with In Vitro Transfection Efficiency
3.16 Ionic Gelled Carboxyacyl Chitosan Nanoparticle for Effective Delivery of Taxane
3.17 Ionic Gelled Chitosan Nanoparticle to Treat Human Skin Melanoma
3.18 Ionic Gelled Chitosan Nanoparticle for Gene Delivery to Fish
3.19 Ionic Gelled Chitosan Microspheres with Vanillin/Tripolyphosphate for Protein Delivery
3.20 Reseveratrol Loaded Ionic Gelled Chitosan Nanoparticles for Cancer Therapy
3.21 Interleukin Loaded Ionic Gelled Chitosan Nanoparticles for Colorectal Cancer Therapy
3.22 Ionically Gelled Chitosan Nanoparticle with Wound Healing Activity
4 Conclusion
References
5 Ionically Gelled Carboxymethyl Polysaccharides for Drug Delivery
1 Introduction
2 Crosslinking Methods
3 Carboxymethylation
4 Carboxymethyl Polysaccharides in Drug Delivery
4.1 Carboxymethyl Cellulose (CMC)
4.2 Carboxymethyl Chitosan/Chitin (CMCS/CMCN)
4.3 Other Polysaccharides
5 Conclusion
References
6 Polyelectrolyte Complex-Based Ionically Gelled Biopolymeric Systems for Sustained Drug Release
1 Introduction
2 Ionic Gelation and Polyelectrolyte Complexation
3 Polyelectrolyte Complexation-Based Ionically Gelled Biopolymers
3.1 Chitosan
3.2 Alginate
3.3 Carrageenan
3.4 Cellulose
3.5 Curdlan
3.6 Dextran
3.7 Gelatin
3.8 Hyaluronic Acid
3.9 Pectin
3.10 Starch
3.11 Xanthan Gum
References
7 Ionically Gelled Polysaccharide-Based Interpenetrating Polymer Network Systems for Drug Delivery
1 Introduction
2 Biomaterials for Making Drug Delivery Systems
3 Interpenetrating Polymer Networks (IPNs)
4 Polysaccharide-Based IPNs for Drug Delivery
5 Conclusion
References
8 Ionically Gelled Polysaccharide-Based Multiple-Units in Drug Delivery
1 Multiple-Units as Drug Delivery Systems
2 Ionic Gelation of Polysaccharides for Production of Multiple-Unit Drug Delivery Systems
2.1 Ionic Crosslinking of Polysaccharides
2.2 Polyelectrolyte Complexes Formation
3 Ionically Gelled of Multiple-Units Drug Delivery Systems Based on Single Polysaccharide
3.1 Chitosan-Based Systems
3.2 Carrageenan-Based Systems
3.3 Dextran Sulfate-Based Systems
4 Multiple-Units Drug Delivery Systems Based on Ionic Gelation of Several Polymers
4.1 Multilayered Polyelectrolyte Complexes Assembly
References
9 Ionically Gelled Polysaccharide-Based Floating Drug Delivery Systems
1 Introduction
2 Drug Delivery Systems
2.1 Floating Drug Delivery Systems
3 Hydrogels
3.1 Floating Hydrogels
4 Polysaccharide-Based Hydrogels as Biomaterials
4.1 Anionic Polysaccharide
5 Cross-Linker Agent for Floating Hydrogel
5.1 Natural Cross-Linker Agent
5.2 Chemical Cross-Linker Agent
6 Floating Induction Using Pore-Forming Agents
6.1 Sodium Bicarbonate as Pore-Forming Agents
6.2 Calcium Carbonate as Pore-Forming Agents
7 Application of Nanoparticles
8 Controlled Release of Drug Delivery System
8.1 Mechanisms of Burst Release in Polymeric Hydrogels
8.2 Mechanisms of Ionic Polysaccharides
9 Biocompatibility Studies
9.1 Kappa-Carrageenan (κ-Carrageenan) Biocompatibility
10 Conclusion
References