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Ionic Liquid–Mediated Synthesis of Coumarin-3-carboxylic Acids via Knoevenagel Condensation of Meldrum's Acid with ortho-Hydroxyaryl Aldehydes

✍ Scribed by Darvatkar, Nitin B.; Deorukhkar, Amol R.; Bhilare, Sachin V.; Raut, Dilip G.; Salunkhe, Manikrao M.


Book ID
115529000
Publisher
Taylor and Francis Group
Year
2008
Tongue
English
Weight
129 KB
Volume
38
Category
Article
ISSN
0039-7911

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A convenient synthesis of coumarin-3-car
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Coumarin-3-carboxylic acids were obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and Meldrum's acid after a 2 h reflux in ethanol. The less reactive ketones were first reacted with alcoholic ammonia to form ketimines, which were then condensed with Meldrum's acid to gen

Ionic Liquid Mediated Knoevenagel Conden
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