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Ionic Complexes of Biosynthetic Poly(malic acid) and Poly(glutamic acid) as Prospective Drug-Delivery Systems

✍ Scribed by Jose A. Portilla-Arias; Montserrat García-Alvarez; Antxon Martínez de Ilarduya; Sebastián Muñoz-Guerra

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
314 KB
Volume
7
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

The hydrolytic degradability and erythromycin release from stoichiometric ionic complexes of biotechnological poly(β,L‐malic acid)s and poly(γ,D‐glutamic acid)s with alkyltrimethylammonium surfactants were investigated. The influence of pH, temperature and antibiotic load on hydrolysis rate was examined. It was found that poly(malic acid) complexes degraded by a surface erosion mechanism at a higher rate than poly(glutamic acid) complexes, which eroded in bulk. Erythromycin was lodged in the paraffinic subphase of the complexes and upon aging it was delivered according to a sigmoidal profile that appeared to be independent on the antibiotic load.

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