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Ion trap tandem mass spectrometric determination of F2-isoprostanes

✍ Scribed by Cinzia Signorini; Mario Comporti; Gianluca Giorgi

Book ID
102377524
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
205 KB
Volume
38
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

A new tandem mass spectrometry (MS/MS) method based on the use of an ion trap mass spectrometer for the identification and quantitation of F~2~‐isoprostanes has been developed. It consists of two solid‐phase extractions and two derivation steps followed by gas chromatography/negative ion chemical ionization tandem mass spectrometry (GC/NICI‐MS/MS) analysis. This method is highly selective and sensitive and it has been successfully applied to biological samples. Copyright Β© 2003 John Wiley & Sons, Ltd.

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