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Ion transport through liquid membrane by cyclic octapeptides

โœ Scribed by Shunsaku Kimura; Yukio Imanishi

Publisher
Wiley (John Wiley & Sons)
Year
1984
Tongue
English
Weight
688 KB
Volume
23
Category
Article
ISSN
0006-3525

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โœฆ Synopsis

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Synopsis

Cation transport through a chloroform liquid membrane by cyclic octapeptides-cyclo-(Leu-Pro)4, cyclo(Phe-Pro)d, and cycIo[Lys(Z)-Pro]4--was investigated. All of these cyclic octapeptides transported K+ and Ba", and the rate of cation transport was correlated with the ability to extract cations from the aqueous phase to the chloroform phase. Among them, cyclo (Leu-Pro)4 was the most efficient and transported K+ and Ba2+ selectively from other alkali and alkaline earth cations, respectively. The rate of K+ transport by cyclo(Leu-Pro)d was about one-third as fast as that by dicyclohexyl 18-crown-6. Picrate anion transport against its concentration gradient was observed by cyclo(Leu-I'ro)4, which is conjugated with the selective transport of K+. Complex formation in a liposome between cyclo(Leu-Pro)4 and Ba2+ was observed, but the binding constant was low.

๐Ÿ“œ SIMILAR VOLUMES

Ca2+ transport through lipid membrane by
Ca2+ transport through lipid membrane by diastereomer cyclic octapeptides
โœ Shunsaku Kimura; Eiichi Ozeki; Yukio Imanishi ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 537 KB

Effects of the nature and orientation of a side chain in cyclic octapeptides on Ca" transport were examined by using cycld~-Lys(Z)-Sar-~-Leu-Sar], (C8-L), cyclo[~-Lys(Z)-Sar], (C8KS), and their diastereomer cyclic octapeptides, c y c ~o [ L -~y s ( ~) -~a r -D -~u -~a r ] , (C8-D) and CYC~~L-LYS(Z)