Ion mobility spectrometry-mass spectrome
β Charles L Wilkins; Sarah Trimpin
π Library
π
2011
π CRC Press
π English
β¦ LIBER β¦
π
Ion Mobility-Mass Spectrometry : Methods and Protocols
β Scribed by Giuseppe Paglia, Giuseppe Astarita
- Publisher
- Springer US;Humana
- Year
- 2020
- Tongue
- English
- Leaves
- 310
- Series
- Methods in Molecular Biology 2084
- Edition
- 1st ed. 2020
- Category
- Library
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β¦ Synopsis
This book focuses on ion mobility-mass spectrometry (IM-MS) and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of state-of-the-art IM-MS technology for the most common analytical applications. The chapters have been organized into four parts, each dealing with a particular set of IM-MS applications: 1) metabolomics and lipidomics; 2) proteomics and glycomics; 3) imaging and ambient ionization IM-MS; and 4) bioinformatic solutions for analyzing IM-MS data and deriving CCS values. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Ion Mobility-Mass Spectrometry: Methods and Protocols serves as an ideal resource for scientists delving into the technique's unprecedented analytical advantages, enabling novel qualitative and quantitative applications for the analysis of complex biological samples.
β¦ Table of Contents
Front Matter ....Pages i-xi
Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules (Caleb B. Morris, James C. Poland, Jody C. May, John A. McLean)....Pages 1-31
Front Matter ....Pages 33-33
Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics (Melanie T. Odenkirk, Erin S. Baker)....Pages 35-54
Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry (Rick Reisdorph, Cole Michel, Kevin Quinn, Katrina Doenges, Nichole Reisdorph)....Pages 55-78
Drift-Tube Ion Mobility-Mass Spectrometry for Nontargeted β²Omics (Tim J. Causon, Ruwan T. Kurulugama, Stephan Hann)....Pages 79-94
The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines (Nicholas B. Vera, Michelle Clasquin, Stephen L. Coy, Paul Vouros)....Pages 95-101
Traveling Wave Ion Mobility-Mass Spectrometry to Enhance the Detection of Low Abundance Features in Untargeted Lipidomics (Zeeshan Hamid, Andrea Armirotti)....Pages 103-117
Lipidomics by HILIC-Ion Mobility-Mass Spectrometry (Amy Li, Kelly M. Hines, Libin Xu)....Pages 119-132
A Workflow for the Identification of Mycotoxin Metabolites Using Liquid ChromatographyβIon Mobility-Mass Spectrometry (Laura Righetti, Chiara DallβAsta)....Pages 133-144
Quantitation of Cyclosporin A in Cell Culture Media by Differential Mobility Mass Spectrometry (DMS-MS/MS) (Amol Kafle, James Glick, Stephen L. Coy, Paul Vouros)....Pages 145-157
Front Matter ....Pages 159-159
An Analytical Perspective on Protein Analysis and Discovery Proteomics by Ion Mobility-Mass Spectrometry (Johannes P. C. Vissers, Michael McCullagh)....Pages 161-178
Ion Mobility-Mass Spectrometry to Evaluate the Effects of Protein Modification or Small Molecule Binding on Protein Dynamics (Lauren J. Tomlinson, Claire E. Eyers)....Pages 179-190
Liquid Extraction Surface Analysis (LESA) High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins (Rian L. Griffiths, Klaudia I. Kocurek, Helen J. Cooper)....Pages 191-201
Ion Mobility-Mass Spectrometry of Glycoconjugates (Weston B. Struwe, David J. Harvey)....Pages 203-219
Front Matter ....Pages 221-221
Desorption Atmospheric Pressure Photoionization Coupled with Ion Mobility-Mass Spectrometry (Tiina J. Kauppila)....Pages 223-233
Metabolomic Profiling of Adherent Mammalian Cells In Situ by LAESI-MS with Ion Mobility Separation (Sylwia A. Stopka, Akos Vertes)....Pages 235-244
Matrix-Assisted Laser Desorption and Desorption Electrospray Ionization Mass Spectrometry Coupled to Ion Mobility (James I. Langridge, Emmanuelle Claude)....Pages 245-265
Front Matter ....Pages 267-267
The Use of LipidIMMS Analyzer for Lipid Identification in Ion Mobility-Mass Spectrometry-Based Untargeted Lipidomics (Xi Chen, Zhiwei Zhou, Zheng-Jiang Zhu)....Pages 269-282
MolFind2: A Protocol for Acquiring and Integrating MS3 Data to Improve In Silico Chemical Structure Elucidation for Metabolomics (Milinda A. Samaraweera, Dennis W. Hill, David F. Grant)....Pages 283-295
Collision Cross Section Calculations Using HPCCS (Gabriel Heerdt, Leandro Zanotto, Paulo C. T. Souza, Guido Araujo, Munir S. Skaf)....Pages 297-310
Back Matter ....Pages 311-312
β¦ Subjects
Life Sciences; Biochemistry, general; Mass Spectrometry
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