Ion chromatographic determination of salicylate in human serum with a bulk acoustic wave sensor as detector
✍ Scribed by Bing-Sheng, Yu ;Li-Hua, Nie ;Shou-Zhuo, Tao
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 407 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0935-6304
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✦ Synopsis
Abstract
Salicylate is a hydrolysis product of salicylate‐containing drugs (such as aspirin) in patients' blood. Monitoring of this ion in blood is helpful for diagnosing of overdosage of these drugs. The present paper describes an ion chromatography (IC) method developed for determination of total salicylate in human serum, in which a hulk acoustic wave (BAW) sensor was used as detector; 0.5 mmoI/L sodium carbonate (Na~2~CO~3~, pH 8.5) served as mobile phase. Interference in the determination was negligible. The method is simple, rapid, accurate, and precise. Serum salicylate was analyzed using both the proposed IC‐BAW method and the classical Trinder spec‐trophotometric method, and the results showed that the two method agreed well.