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Ion channel stability and hydrogen bonding molecular modelling of channels formed by synthetic alamethicin analogues

✍ Scribed by J. Breed; I.D. Kerr; G. Molle; H. Duclohier; M.S.P. Sansom


Book ID
117048807
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
565 KB
Volume
1330
Category
Article
ISSN
0005-2736

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Dimerization models of c-erbB2 transmembrane domains (Leu651-Ile675) are studied by molecular mechanics and molecular dynamics simulations. Both wild and Glu mutated transmembrane helices exhibit the same relative orientation for favorable associations and dimerize preferentially in left-handed coil