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Ion channel and membrane translocation of diphtheria toxin

✍ Scribed by Cesare Montecucco; Emanuele Papini; Giampietro Schiavo; Elisabetta Padovan; Ornella Rossetto

Book ID
109318022
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
925 KB
Volume
105
Category
Article
ISSN
0378-1097

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Roles of Glu 349 and Asp 352 in membrane
Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin
✍ Poonam Kaul; Jared Silverman; Wei Hai Shen; Steven R. Blanke; Paul D. Huynh; Ala πŸ“‚ Article πŸ“… 2008 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 644 KB

## Abstract Acidic conditions within the endosomal lumen induce the T domain of receptor‐bound diphtheria toxin (DT) to insert into the endosomal membrane and mediate translocation of the toxin's catalytic domain to the cytosol. A conformational rearrangement in the toxin occurring near pH 5 allows