Iodine-induced hypothyroidism and goiter following lipiodolTMlymphography

✍ Scribed by P. H. Heidemann; P. Stubbe; P. Schürnbrand; G. Prindull

• Book ID: 104775788
• Publisher: Springer
• Year: 1982
• Tongue: English
• Weight: 258 KB
• Volume: 138
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00442337

✦ Synopsis

Hypothyroid goiter is a rare but well recognized complication following long term administration of iodine containing expectorants and disinfectants in children. Only few reports exist on iodine-induced hypothyroidism after a single inj ection of the iodized radiopaque dye Lipiodol. A 15-year-old boy with previously normal thyroid function is described who developed hypothyroid goiter within six weeks following bipedal lymphography. Urinary iodine excretion was extremely elevated up to 18 rag/day while serum concentrations of total thyroxine were below the euthyroid range and thyrotropin levels were elevated. After oral L-thyroxine treatment the goiter disappeared. Thyroid function remained normal when treatment was discontinued after five months although iodine excretion was still 50 times higher (2.5 rag/day) than in normal age matched children, The observed alterations of the thyroid gland were caused by a long lasting Wolff-Chaikoff effect with a delayed adaptation to high iodide concentrations.