Five novel inactivating mutations in the
β
Carina M. Rivolta; SebastiΓ‘n A. Esperante; Laura GruΓ±eiro-Papendieck; Ana Chiesa
π
Article
π
2003
π
John Wiley and Sons
π
English
β 47 KB
Thyroid peroxidase (TPO) defects, typically transmitted as autosomal recessive traits, result in hypothyroid goiters with failure to convert iodide into organic iodine. We analyzed the TPO gene in 14 unrelated patients with clinical evidence of iodide organification defects. Seven of the affected in