In this study, we investigated the expression of genes for inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-a), interleukin 1b (IL-1b), interleukin 6 (IL-6) of Kupffer cells in the presence of lipopolysaccharide (LPS), and the tissue expression of iNOS in a rat liver after LP
Involvement of various combinations of endogenous inflammatory cytokines in Listeria monocytogenes-induced expression of inducible nitric oxide synthase in mice
β Scribed by Huabao Xiong; Takeaki Nishibori; Satoshi Ohya; Yoshinari Tanabe; Masao Mitsuyama
- Book ID
- 109307187
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 904 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0928-8244
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## Abstract The present study underlines the importance of phospholipase A~2~ (PLA~2~)β and lipoxygenase (LO)βmediated signaling processes in the regulation of inducible nitric oxide synthase (iNOS) gene expression. In glial cells, lipopolysaccharide (LPS) induced the activities of PLA~2~ (calciumβ
Combinations of cytokines andor phorbol ester induce expression of Type I1 nitric oxide synthase (NOS) mRNA in astrocyte cultures via protein kinase mediated pathways (Simmons and Murphy: GLIA 11:227,1994; Feinstein et al.: J Neurochem 62:811, 1994). Agonists that activate receptors linked to protei