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Involvement of tumor necrosis factor (TNF)-α in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice

✍ Scribed by Masao Murakawa; Kumiko Yamaoka; Yoshitaka Tanaka; Yoshiaki Fukuda

Book ID: 113487898
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 287 KB
Volume: 71
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2006.01.005

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## Abstract To assess the requirements for papilloma formation in transgenic mice that over express transforming growth facto‐α (TGF‐α) in the epidermis (HK1.TGFα), we tested the sensitivity of HK1 TGFα mice to tumor promotion with 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA) and analyzed the res