Human melanoma represents one of the most metastatic cancers in man. The capacity of melanoma cells to invade a variety of tissues and extracellular matrices is, in part, due to their repertoire of adhesion receptors. To this end, human melanoma cells express multiple integrin cell adhesion receptor
Involvement of tumor cell integrin αvβ3 in hematogenous metastasis of human melanoma cells
✍ Scribed by Brunhilde Felding-Habermann; Emilia Fransvea; Timothy E. O'Toole; Lisa Manzuk; Barbara Faha; Mary Hensler
- Book ID
- 110347994
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 167 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0262-0898
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Long-term administration of pharmacological doses of glucocorticoids inhibits bone formation and results in osteoporosis. Since integrin-mediated cell-matrix interactions are essential for osteoblast function, we hypothesized that the detrimental effect of glucocorticoids on bone derived, at least i
## Abstract Chondrosarcoma is a type of highly malignant tumour with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Tumour necrosis factor (TNF)‐α is a key cytokine involved in inflammation, immunity, cellular homeo
## Abstract Previous studies indicated that transfection of the platelet integrin αIIbβ3 into human melanoma cells expressing integrin αvβ3 promoted their __in vivo__ (but not __in vitro__) growth and cell survival. To reveal the underlying pathomechanism, we have analyzed the angiogenic phenotype