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Involvement of the ryanodine-sensitive Ca2+store in GLP-1-induced Ca2+oscillations in insulin-secreting HIT cells

✍ Scribed by Sadao Sasaki; Ikuko Nakagaki; Hisao Kondo; Seiki Hori


Publisher
Springer
Year
2002
Tongue
English
Weight
467 KB
Volume
445
Category
Article
ISSN
0031-6768

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## Abstract Studies with in‐vitro‐cultured neurons treated with amyloid‐β (Aβ) peptides demonstrated neuronal loss by apoptosis that is due, at least in part, to the perturbation of intracellular Ca^2+^ homeostasis. In addition, it was shown that an endoplasmic reticulum (ER)‐specific apoptotic pat