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Involvement of the Ras/MAPK Signaling Pathway in the Modulation of Urokinase Production and Cellular Invasiveness by Transforming Growth Factor-β1 in Transformed Keratinocytes

✍ Scribed by Juan F. Santibáñez; Maite Iglesias; Pilar Frontelo; Jorge Martı́nez; Miguel Quintanilla


Book ID
115586031
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
254 KB
Volume
273
Category
Article
ISSN
0006-291X

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## Abstract Amphireguline (AR) is an epidermal growth factor (EGF)‐related peptide that seems to play an important role in breast cancer progression. We have demonstrated recently that suppression of AR expression in transformed breast epithelial cells considerably reduced both size and neovascular