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Involvement of the PI3K/AKT pathway in ATP-induced proliferation of developing retinal cells in culture

✍ Scribed by Isis Moraes Ornelas; Ana Lucia Marques Ventura

Book ID: 116552132
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 677 KB
Volume: 28
Category: Article
ISSN: 0736-5748
DOI: 10.1016/j.ijdevneu.2010.06.001

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Phenotype transition of vascular smooth muscle cells (VSMCs) is important in vascular diseases, such as atherosclerosis and restenosis. Once released, ATP may promote activation of VSMCs by stimulating cyclooxygenase-2 (COX-2), cytosolic phospholipase A 2 (cPLA 2 ) expression and prostaglandin (PG)E