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Involvement of sulfhydryl groups in the oxidative modulation of particulate lung guanylate cyclase by nitric oxide and N-methyl-N′-nitro-N-nitrosoguanidine

✍ Scribed by J.Mark Braughler


Book ID
115776002
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
784 KB
Volume
31
Category
Article
ISSN
0006-2952

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The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased colonic mucosal cGMP from 1.8 f 03 to 22.5 f 2.7 pmol/mg protein in 5 minutes. Increases in response to MNNG o