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Involvement of substance P in the paroxysmal cough of pertussis

โœ Scribed by S. Yoshihara; N. Kanno; T. Ando; N. Fukuda; T. Abe; T. Ichimura; N. Yanaihara


Book ID
119117757
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
45 KB
Volume
37
Category
Article
ISSN
0167-0115

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Role of Substance P in Cough
โœ Kiyohisa Sekizawa; Yu Xia Jia; Takae Ebihara; Yuko Hirose; Yoshitaka Hirayama; H ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier ๐ŸŒ English โš– 243 KB

The sensory neuropeptide, substance P (SP), is present in human airway nerves, beneath and within the epithelium where the condensed localization of neutral endopeptidase (NEP), the major enzyme degrading SP, is observed. To test the hypothesis whether SP stimulates the cough reflex and NEP modifies