Involvement of stromal p53 in tumor-stroma interactions
β Scribed by Jair Bar; Neta Moskovits; Moshe Oren
- Book ID
- 116881540
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 378 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1084-9521
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Fibrogenesis, expressed as βdesmoplasia,β is found in many kinds of tumors and considered to be associated with malignancy. In fact, fibroblasts in cancer stroma have attracted considerable attention in the last 2 decades. Although it is accepted that fibroblasts are important in tumor
## Abstract The efficacy of chemotherapy is usually viewed as the outcome of cancerβcellβautonomous processes while the contribution of stroma is being overseen. Here we show that p53 mutations in stromal fibroblasts, a genetic lesion that is detectable in primary breast, prostate and probably othe