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Involvement of Rho-kinase in prostaglandin E1-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells

✍ Scribed by Seiji Adachi; Haruhiko Tokuda; Rie Matsushima-Nishiwaki; Kenji Kato; Hideo Natsume; Chiho Minamitani; Jun Mizutani; Takanobu Otsuka; Osamu Kozawa


Book ID
113865138
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
545 KB
Volume
90
Category
Article
ISSN
0090-6980

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## Abstract Inhibition of osteoblast‐mediated mineralization is one of the major catabolic effects of parathyroid hormone (PTH) on bone. Previously, we showed that PTH induces matrix γ‐carboxyglutamic acid (Gla) protein (MGP) expression and established that this induction is critical for PTH‐mediat