INVOLVEMENT OF PI 3-KINASE, PKA AND PKC IN PDGF- AND TGF-β-MEDIATED PREVENTION OF 2-DEOXY-D-RIBOSE-INDUCED APOPTOSIS IN THE INSECT CELL LINE, IPLB-LdFB
✍ Scribed by Enzo Ottaviani; Daniela Barbieri; Davide Malagoli; Dimitris Kletsas
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 158 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1065-6995
No coin nor oath required. For personal study only.
✦ Synopsis
Activation of phosphatidylinositol (PI) 3‐kinase, protein kinase A (PKA) and protein kinase C (PKC) is associated with the survival effect elicited by PDGF‐AB and TGF‐β1 against the apoptotic inducer 2‐deoxy‐D‐ribose (dRib) in the fat body cell line, IPLB‐LdFB, from the insect Lymantria dispar. dRib induces apoptosis and provokes mitochondrial membrane depolarization (MMD). The antioxidant N ‐acetyl‐L‐cysteine annuls only the first effect. These findings suggest that apoptosis and MMD are provoked by two different mechanisms, and that dRib induces apoptosis by oxidative stress.